Sparticle.org - this is more for older students, but there are some great videos, games, and hand-on activities that let you explore various STEM (science, technology, engineering and math) topic.
goREACT! Do you want to explore chemical reaction? Use the periodic table to mix things together and see what you get!
Scholastic Computer Games - click on the Science heading and play some of the games.
Museum of Natural History in New York City - great kids activities, games, and things to explore
Science Music Videos
Ecological Footprint Quizzes
Interesting Sites